Accelerate biotechnology

Meet the experts

    How important is matrix effect in analyzing bioprocess samples?
    Meet the Expert: Petra, Analytical Scientist The matrix effect is the effect on an analytical assay caused by all other components of the sample except the specific compound (analyte) to be analyzed. Matrix effects can be observed either as a loss in response – resulting in an underestimation of the amount of…

    Do fixed-bed bioreactors provide a solution to viral vector shortage?
    Meet the Expert: Yang, Bioprocess Scientist In 2017, the New York Times wrote an article to report the critical shortage in the global viral vector manufacturing capacity. Next to the shortage of experienced manufacturing organizations capable of producing viral vectors, the high costs to produce this material is a main challenge for patients…

    Challenges in virus-based manufacturing in GMP
    Meet the Expert: Marije, GMP Scientist Many customers want to know how much time it will take to move a candidate viral vaccine or viral vector product from bench to bed and what shortcuts can be taken in order to move even faster. Having strong pre-clinical data from in vivo experiments showing…

    Analytical assay development: go ALL the way
    Meet the Expert: Gert, Analytical Assay Scientist The truth is; the accuracy and robustness of any process under development or manufacturing outcome is only as good as the reliability of the assays needed to understand the process. The effort involved to get to a comfortable situation where all necessary tests are available,…

    Latest advancements in bioprocess intensification for efficient biopharmaceutical production
    Meet the Expert: Ahd, Bioprocess Project Director Current costs of biopharmaceutical manufacturing often prevent segments of the world’s population from accessing critical medicines or even prevent medicines from being marketed. A significant part of these costs come from the need for large and expensive manufacturing facilities. This hurdle can be overcome by…

    Genetic stability studies: could process parameters change your virus?
    Meet the Expert: Monika, Viral vector scientist Despite having very limited coding capacity, most of the RNA viruses are surprisingly good at escaping the hosts immune response and withstanding antiviral drugs. RNA viruses achieve this by virtue of their ability to multiply rapidly, coupled with their high mutation rate compared to DNA viruses. An important…

    Tackling the capacity bottleneck in downstream processing of viral vectors
    Meet the Expert: Evert, Associate Director DSP With the first gene therapies now being on the market, the production quantities for gene therapy vectors are increasing to satisfy the demand. A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of viral…

    In manufacturing it’s ALL about Quality Control
    Meet the Expert: Caroline, Quality Control Scientist The Quality Control (QC) department performs analytical development, assay qualification, assay validation, testing on raw materials, cell substrates and cell banks. Also, the department is heavily involved in the “in-process” testing as well as testing the final drug substance and drug product. In addition, QC…

    Drivers in selecting a reliable partner for clinical GMP manufacturing
    Meet the Expert: Pim, GMP Scientist One of the most sought-after outsourcing demands in life sciences is clinical GMP manufacturing and release of biopharmaceutical products to allow subsequent testing in human subjects for safety and efficacy. Globally the market for this outsourcing activity is estimated at about $3 billion annually, of which…

    Quality specialist is key in any biopharmaceutical development team
    Meet the Expert: Margreet, QA specialist The ability to translate biopharmaceutical research into products is known to have a high failure rate. A staggering 75% of published pre-clinical data cannot be reproduced or validated to allow further product development1. I believe that the only way to prevent such disappointments both scientifically, as…

    Novel HPLC assays allow for better biopharmaceutical development
    Meet the expert: Rinske, Associate Director Analytical Assays. HPLC has been widely used for decades in the analysis of small molecules and is gaining momentum as an important tool for analyzing biotechnology products. For instance, HPLC has been successfully introduced for the analysis of monoclonal antibody-based products and is more and more…

    How to scale your adherent cell culture
    Meet the expert: Matthijs, Associate Director Upstream Bioprocessing Cells derived from mammalian species and cultured under artificial laboratory conditions have been used to produce complex biological products. As such cells normally grow as a tissue, most available artificial mammalian cells are originally surface-dependent and therefore are called adherent cells. Adherent cells will…

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