Accelerate biotechnology

Meet the experts

    Genetic stability studies: could process parameters change your virus?Meet the Expert: Monika, Viral vector scientist Despite having very limited coding capacity, most of the RNA viruses are surprisingly good at escaping the hosts immune response and withstanding antiviral drugs. RNA viruses achieve this by virtue of their ability to multiply rapidly, coupled with their high mutation rate compared to DNA viruses. An important…
    Tackling the capacity bottleneck in downstream processing of viral vectorsMeet the Expert: Paddy, DSP scientist With the first gene therapies now being on the market, the production quantities for gene therapy vectors are increasing to satisfy the demand. A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of viral vector…
    In manufacturing it’s ALL about Quality ControlMeet the Expert: Freek, Quality Control / Validation Scientist The Quality Control (QC) department performs analytical development, assay qualification, assay validation, testing on raw materials, cell substrates and cell banks. Also, the department is heavily involved in the “in-process” testing as well as testing the final drug substance and drug product. In…
    Drivers in selecting a reliable partner for clinical GMP manufacturingMeet the Expert: Pim, GMP Scientist One of the most sought-after outsourcing demands in life sciences is clinical GMP manufacturing and release of biopharmaceutical products to allow subsequent testing in human subjects for safety and efficacy. Globally the market for this outsourcing activity is estimated at about $3 billion annually, of which…
    Quality specialist is key in any biopharmaceutical development teamMeet the Expert: Margreet, QA specialist The ability to translate biopharmaceutical research into products is known to have a high failure rate. A staggering 75% of published pre-clinical data cannot be reproduced or validated to allow further product development1. I believe that the only way to prevent such disappointments both scientifically, as…
    How to scale your adherent cell cultureMeet the expert: Matthijs, Bioprocess Scientist. Cells derived from mammalian species and cultured under artificial laboratory conditions have been used to produce complex biological products. As such cells normally grow as a tissue, most available artificial mammalian cells are originally surface-dependent and therefore are called adherent cells. Adherent cells will only duplicate…

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